在exon 1的5'端插入了一个loxP位点,然后在intron 1插入了一个含loxP标记的诺卡因和胸腺嘧啶激酶选择性载体。在将选择性载体通过转暂时的Cre重组酶表达从ES细胞中去除后,产生了小鼠。最终的等位基因在exon 1的两侧有loxP位点。(来源:J:63517)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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