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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Nkx2-5
tm2(cre)Rph
Alias:
Nkx2-5
IRESCre
Nkx2.5-Cre
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基础信息
表型特征
文献报道
将连接了Cre重组酶的内含子插入到原基因3' UTR中,通过同源重组。经Frt标记的Hygromycin筛选 cassette切除后,UTR中保留了一个Frt座。未观察到等位基因补救现象,表明插入序列对原基因表达影响不大。(来源:J:80725)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
2448972
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
23
72
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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