The transgene consists of a 2.3 kb cDNA of a lymphoma-specific isoform (G1/p57) of RUNX2, and a human CD2 promoter. The human CD2 promoter was used to drive expression in T lymphocytes. Northern blot analysis of transgenic tissues revealed transgene expression in thymus, spleen, and mesenteric lymph node. Transgene expression was confirmed by Western blot analysis of thymocytes. (J:59021)