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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
转基因模型
Tg(Vil1-cre)997Gum
Alias:
Villin-cre
Vil-Cre
V
cre
Villin.cre
Tg(Vil-cre)
997Gum
VilCre
VillinCre
12.4KbVilCre
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基础信息
表型特征
文献报道
来自villin 1基因的12.4千碱基序驱动表达cre重组酶cDNA,包括金属硫蛋白序列和poly(A)信号。重组发生在小肠和大肠的绒毛和隐窝细胞中,精确调控了内源基因的表达。共产生了七条转基因品系。根据作者J:78815所述,表达通常是连续的,但在结肠中观察到轻微的嵌合现象。转基因表达开始于12.5日胚胎干期,比内源性mouse Vil基因的表达开始时间(9.0日胚胎干期)晚。品系997中,转录本插入了17号染色体,位于St6gal2(chr17:55,466,255;NCBI37/mm9)大约119千碱基上游,整合位点伴有14.6千碱基的缺失。(J:78815)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
2448639
(C57BL/6J x SJL)F1
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Insertion, Intergenic deletion
--
--
--
638
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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