在转基因小鼠中,通过体内Cre介导的重组,从Prkaa2tm1Vio中去除了包含第189到第260位氨基酸编码序列的floxed区域以及下游的neo cassette。对来自纯合突变小鼠的肝脏和肌肉组织进行 Western blot 分析,未检测到蛋白质。(来源:J:81120)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
--
107

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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