内源性位点的Exon 2被一个包含β-gal和neo基因的 cassette 替换,产生了特异性的等位基因变异。Exon 2是Citron-K亚型的第二个编码外显子,位于Citron-N转录起始点的上游。在杂合突变小鼠的脑、脾和胸腺组织的 Western blot 检测中,未检测到Citron-K亚型,而Citron-N亚型的水平正常。(来源:J:77297)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count