Exon 2被替换了通过同源重组插入的诺姆西林选择座。删除区域编码了39个氨基酸。脑匀浆的 Western blot 分析显示,纯合突变小鼠中没有检测到蛋白。(来源:J:68187)
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Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 39 amino acids. Western blot analysis of brain homogenates indicated an absence of protein in homozygous mutant mice. (J:68187)