在Znfn1a1tm1(Pax)Mbu动物与表达Cre的TgN(Sycp1-cre)4Min线性杂交后,去除了exon 2中的floxed neo cassette,这样就可以在Znfn1a1基因上通过Pax5-GFP cassette的表达。 Western blot结果显示,胸腺细胞和髓细胞中的Pax5蛋白表达水平与野生型相似。B细胞中的GFP表达通过流式细胞术分析得以检测到。(来源:J:80815)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
插入
--
1
4
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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