这个基因通过同源重组的方式,用诺美西林抗性基因 cassette 替换了5-7号外显子,导致其失活。通过Northern和Western印迹分析确认了基因表达的缺失。在纯合突变动物的肝脏RNA中未检测到基因转录,而在测试的多个组织中也未观察到蛋白质产物。(来源:J:80831)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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