Lta基因和大部分Tnf基因(编码至exon4的第113位密码子)被通过同源重组插入了诺卡因选择标记。通过Northern blot分析的趋化素A刺激脾细胞和巨噬细胞集落上清液的ELISA检测,未发现转录或部分蛋白质。在LPS刺激下,纯合突变小鼠中未检测到Tnf活性。(来源:J:39519)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
Insertion, Intergenic deletion
--
1
3
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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