Tg(MMTV-Myc)147-9bLed

The transgene contains the mouse mammary tumor virus promoter and the mouse myelocytomatosis oncogene and the endogenous Myc promoters. The MMTV promoter droved transgenic expression in the spleen, testis, lung, brain, salivary gland, and mammary (J:72130) and preputial gland. Expression of the transgene was not detected in thymus, pancreas, kidney, liver, heart, or muscle. Five to ten copies of the transgene were inserted at the site of integration. The founder mouse that gave rise to this strain carried two insertions of the transgene, which were separated by breeding into lines carrying either Tg(MMTV-cmyc)147-9aLed or Tg(MMTV-cmyc)147-9bLed. (J:29013)