Tg(Gfap-Il12a,Gfap-Il12b)GFIl12Ilc

In this transgenic line, two constructs were coinjected and cointegrated in the genome. The first construct consists of a mouse IL12a sequence (nucleotides 14-819) under the control of a mouse Gfap promoter. The second construct consists of a mouse IL12b sequence (nucleotides 1-1055) under the control of a mouse Gfap promoter. The mouse Gfap promoter was used to drive transgene expression in astrocytes. A human growth hormone polyadenylation sequence and SV40 splice donor/acceptor site were also included in the constructs. (J:72989)