Tg(Col2a1-Runx2)2Tok

The entire coding region of mouse Runx2 (with translation starting from exon 1) was cloned between the promoter and enhancer elements of Col2a1, which were used to drive transgene expression in chondrocytes. Transgene expression was confirmed by Northern blot analysis of RNA extracted from the head or trunk of day E12.5 transgenic embryos. Both type I and type II isoforms are expressed from this transgene. (J:68793)