一段2kb的基因区域,包括exon2和exon3,以及锌指编码区域,被替换为一个与lacZ序列和PGK-neo cassette相接的同框插入。预期这个靶向等位基因会产生一个Snai2和β-半乳糖苷酶融合蛋白,前120个氨基酸来自Snai2。对突变胚胎的整体制片原位杂交分析显示,lacZ的表达模式与内源性Snai2一致。(来源:J:48521)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
2
12

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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