这个等位基因是由通过杂交突变动物与Cre敲除杂交株TgN(CMV-cre)1Cgn产生的,后代缺失了含floxed neo cassette的元件,取而代之的是在第1和内含子1位置有一个LoxP位点。通过对自然杀伤细胞(NK细胞)和CD8+细胞的提取物进行 Western blot 分析,确认了纯合突变动物中基因表达的缺失。(来源:J:80426)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
22

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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