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The exon encoding the beginning of the protein's kinase-like domain was deleted via in vitro Cre-mediated recombination in targeted ES cells between a single upstream loxP site and the 3' loxP site of a downstream loxP-flanked neor-tk cassette. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. (J:71950)