Hoxd11, Hoxd12, Hoxd13, and regions VIII through XI were deleted via trans-allelic meiotic recombination (TAMERE). The deletion was accomplished by recombination of a single loxP site in the intergenic region between Evx2 and Hoxd13 (Evx2/Hoxd13tm1.1Ddu) and a single loxP on the opposite chromosome downstream of region XI (Hoxdtm5Ddu). (J:80084)