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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Del(2Hoxd12-Hoxd13)5Ddu
Alias:
Hoxd
tm8Ddu
HoxD
del(d13-12)
Del5Ddu
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基础信息
表型特征
文献报道
Hoxd13、Hoxd12以及区域X和XI通过同源重组的转基因方法进行了删除。这项操作通过在Evx2和Hoxd13基因间的一个loxP位点的重组实现,Evx2/Hoxd13tm1.1Ddu标记中包含Evx2的首编码框一个终止密码子在110bp位置。另外,一个loxP标记位于303bp在染色体的对面,紧接着一个261bp区域X的删除区域。来源:(J:80084)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
2445976
129S2/SvPas
Targeted
Intergenic deletion, Intragenic deletion
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4
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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