通过同源重组在exon 3内插入无启动子的诺卡因选择标记,实现了特异性的基因剪接突变。在纯合突变小鼠的RT-PCR分析中未检测到gamma1转录,然而gamma2 mRNA能轻易被扩增。RNAse保护实验进一步证实了gamma1亚型的缺失。(来源:J:42773)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count