通过同源重组在exon 3内插入无启动子的诺卡因选择标记,实现了特异性的基因剪接突变。在纯合突变小鼠的RT-PCR分析中未检测到gamma1转录,然而gamma2 mRNA能轻易被扩增。RNAse保护实验进一步证实了gamma1亚型的缺失。(来源:J:42773)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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