Exon 2被新霉素筛选 cassette 的插入所打断。通过 Western blot 分析或胰腺提取物的生化测定,无论是蛋白质还是磷脂水解活性,在纯合突变小鼠中均未检测到(来源:J:68430)
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Exon 2 was disrupted by the insertion of a neomycin selection cassette. Neither protein nor phospholipid hydrolytic activity was detected in homozygous mutant mice by Western blot analysis or biochemical assay of pancreatic extracts. (J:68430)