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中文
内源性位点通过插入一个构建改造，该构建包含兔β-球蛋白的3'剪接位点，后面跟着Cre/ERT融合基因，编码的Cre重组酶与人雌激素受体的G321R突变激素结合域连接，该域对4-羟基他莫昔芬(4-OHT)呈活化，而不对天然的ER配体17β-雌二醇起作用。融合基因后面跟着兔β-球蛋白的polyadenylation信号和一个PGK-puro(抗puromycin)基因座。在携带了敲除报告基因的转基因小鼠中，有效Cre介导的重组被报道反映Gt(ROSA)26Sor在胚胎期及以后的持续表达。(来源：J:80160)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
