将PGK-neo cassette插入第2外显子,打断了编码第三个跨膜区的序列。尽管Northern印迹分析在纯合突变小鼠中检测到了一些异常转录本,但没有正常转录本被发现。使用标记的血栓烷激动剂的结合分析显示,这些小鼠的胸腺细胞和肾组织中均无功能受体存在。(来源:J:52125)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
1
20

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部