通过lacZ和neo构建的元件的同源重组导致了exon 3的一部分缺失,以及exons 4到7的全部,这些区域编码了从200到1380的氨基酸,对应于蛋白激酶A和leucine zipper区域。在肾、肝和睾丸的Western blot分析中,没有检测到同源突变纯合子小鼠的蛋白质。β-galactosidase染色显示lacZ的表达模式与内源基因相似。(来源:J:74982)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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