经过修改的鼠基质金属蛋白酶3(Mmp3)序列被连接到一个2.4kb的小鼠Wap启动子片段。Mmp3序列在第92位由缬氨酸替换为甘氨酸,导致了自激活。免疫细胞化学分析显示,在孕鼠和乳鼠的乳腺组织中检测到了大量转基因蛋白。(来源:18003)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
CD-1
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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