一段人类的cDNA,它编码了一个在C端被截短的TGFBR2,被附加到了MMTV调控区。这个编码的受体包含了完整的外周和跨膜区域,能够结合配体并和类型1受体互动,但没有酪氨酸激酶部分。表达是在乳腺上皮细胞中通过MMTV的LTR启动子/增强子驱动的。转基因表达通过Northern blot分析进行了验证。(来源:J:46432)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x DBA)F2
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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