Tg(Hsp70-1-cre)6Arge

A sequence fragment from the murine Hsp70-1 locus encompassing 655 bp of the 5' flanking and noncoding sequence was adjoined to sequence encoding cre recombinase. A single integration of the transgenic construct was identified in the founder line. Graded expression of the transgenic construct (determined by a range of 0% to 100% recombination of reporter loci) was observed in non heat shock induced embryos. Additionally, heat shock induces expression. (J:60711)