Adgrv1^frings

The phenotype of the Frings mouse has been attributed to a single nucleotide deletion (guanine 7009) that results in a nonsense mutation in exon 27 (codon 2072). The stop codon putatively precludes translation of a multicopper oxidase (MCOI) consensus site in all three splice variants. The allele was originally described in RB/1 strain, but subsequently the same mutation was found in BUB/BnJ strain but not in 11 other strains of Swiss albino mice. (J:71344)