将牛β肾上腺素受体激酶-1(ADRBK1)的羧基端序列(495至689位)编码起来,并与小鼠成年心肌肌动蛋白重链6(Myh6)心肌α型启动子的5.5kb片段连接。生成的194个残基羧基端肽通过 Western blot 分析得以检测,能抑制内源性β肾上腺素受体激酶-1,通过阻断β肾上腺素受体的失敏作用。Myh6启动子驱动心肌组织中的表达。(来源:J:37034)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F1
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1
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15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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