从1到4号外显子的编码区域被一个包含lacZ和一个floxed neo的 cassette 替换。通过对雄性半合子小鼠脑组织进行 Western blot 分析,未检测到蛋白质。(来源:J:79454)
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The coding regions of exons 1 through 4 were replaced by a cassette containing lacZ followed by a floxed neo. Protein was undetected by Western blot analysis of brain tissue obtained from male hemizygous mice. (J:79454)