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中文
使用了一种靶向构建，其中Psme1的2-10号外显子被抗氨苄青霉素抗性基因 cassette 替换，而Psme2的2-10号外显子被删除，这样在单一的同源重组事件中同时打乱了这两个位置。位于Psme1和Psme2之间的Cgi112基因（基因ID：1500005A01Rik）序列保持不变。对来自纯合突变胚胎培养的鼠胚胎成纤维细胞（MEFs）进行的Northern blot和Western blot分析确认了Psme1和Psme2基因表达的缺失。（来源：J:72533）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
