将Hoxa3基因的整个编码区域替换为Hoxd3基因的编码区域,5'和3'的上游下游序列以及内含子都来自Hoxa3位点。Hox3d替换基因的3'端连接了一个11个氨基酸的c-myc抗原表位,后面跟着一个能自我剪切的诺卡因抗性载体。当去除了诺卡因载体后,会留下一个loxP位点。(来源:J:60296)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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