这个转基因包含了人类RET基因的cDNA,编码RET51亚型,其中第918位的甲硫氨酸被替换成丝氨酸(M918T),并和小鼠Hoxb7启动子序列(-1316到+81)相连。Hoxb7小鼠的启动子被用来驱动转基因在整个输尿管芽分支中的表达。M918T突变与人类的MEN2B综合症相关。(来源:J:71588)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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