这个转基因包含了人类RET基因的cDNA,编码RET9亚型,其中第634位的 cysteine 被替换成了lysine(C634K)。它与mouse Hoxb7启动子序列(从-1316到+81)相连。Hoxb7小鼠的启动子被用来在输尿管芽分支中驱动转基因的表达。C634K变异与人类的MEN2A综合症相关。(来源:J:71588)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
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