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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
转基因模型
Tg(Hoxb7-RET/AKAP1)1Cos
Alias:
Hoxb7/RET-PTC2
Hoxb7/RET9-PTC2
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基础信息
表型特征
文献报道
这个转基因包含了人类RET酪氨酸激酶域与人类AKAP1基因的一部分融合,后面跟着人类β球蛋白的序列。这种融合基因出现在某些乳头状甲状腺癌中,是染色体重组的结果。鼠的Hoxb7基因启动子序列驱动转基因在整个尿道芽分支内的表达。(来源:J:52988)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
2388558
(C57BL/6 x CBA)F2
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插入
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2
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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