Log In|Sign Up
中文
Ptpn11结合区域，由第17号外显子编码，通过同源重组，通过在757位(酪氨酸到苯丙氨酸)和760位(缬氨酸到Alanine)的错义突变构建的构造打乱了。此外，伊里萨克斯-neo插件被插入到17号外显子的3'端。在肝组织的生化实验中，结果显示了在突变小鼠中，Il6st介导的信号通路被干扰。(来源：J:79073)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
