一个ROSABeta-geo基因陷阱载体随机整合到了内源性基因座两个编码外显子之间的内含子中。通过分析来自纯合突变睾丸组织的总RNA进行RT-PCR,未检测到野生型mRNA。相邻基因Madcam1和Cdc34的转录水平正常,表明它们未受插入影响。整合的β-半乳糖苷酶序列的表达模式,通过原位杂交分析,与内源基因的表达模式相似。(来源:J:79292)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Gene trapped
基因捕获载体的插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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