一个包含Krt2-6a和Krt-6b全套编码序列,以及10.5kb的插入序列的18kb区域,通过同源重组被删除并替换为HPRT-neo迷你基因。通过皮肤和毛囊的RNA酶保护实验,确认了这两个基因在纯合突变动物中无表达。(来源:J:70812)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion, Intergenic deletion
--
1
5
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部