为了复制与儿童疾病肺泡细胞横纹肌肉瘤相关的染色体易位(t(2;13)),通过同源重组技术,将PAX3-FOXO1A融合基因cDNA中的序列片段插入了原基因座。原末段exon 7的最后50bp被替换为PAX3序列和FOXO1A的3'端。多项分析显示敲入等位基因的表达水平较低。(来源:J:79365)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部