RIZ1蛋白产物在编码PR域(PR domain)的第5外显子中心插入了抗氨苄青霉素抗性基因元件后被干扰。编码RIZ2蛋白的序列(RIZ2 protein),从第6外显子开始转录,基因靶向事件并未影响其。通过Northern blot分析成年鼠大脑RNA、Western blot检测成年睾丸蛋白以及RT-PCR研究,确实确认了纯合突变动物中RIZ1基因表达的缺失。(来源:J:71406)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部