大约80%的编码区域被同源重组插入的诺卡因选择座替换。删除区域包含推测的膜穿孔区域。通过北向 blot 对大脑组织的分析,该转录本在纯合突变小鼠中未检测到。基于胆红素生成的检测方法显示,纯合突变小鼠功能完全丧失。(来源:J:29523)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
--
53

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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