通过体内Cre介导的裁剪,去除了Dab1tm3Cpr中的floxed neo cassette,插入的271个密码子cDNA片段保持不变。翻译产生的p45蛋白是一个含有30个独特残基的截短蛋白,代替了原有的314个羧基残基。在同源突变小鼠的 Western blot 分析中,只检测到了p45蛋白,没有发现p80。(引用:J:74239)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJaeSor
Targeted
插入
--
1
1
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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