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中文
通过同源重组将lysine-proline-glutamine(1505-1507)序列替换成单个loxP位点，随后通过体外Cre介导的剪切，实现了这个缺失。这个设计旨在模拟LQT3综合征，该病会导致心电图QT间期延长。定量RT-PCR和 Western blot结果显示，靶向等位基因产生的转录和蛋白水平与野生型表达相当。(来源：J:71542)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
