一种含有抗假叶酸基因(ble)和lacZ随机插入内源性位点的基因陷阱载体,构建出了TL15突变的ES细胞系。RT-PCR结果显示,插入事件干扰了神经系统的主导转录,而对睾丸特异性转录的影响相对较小。(来源:J:36630, J:70587)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Gene trapped
基因捕获载体的插入
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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