Fgfr3^tm1Iwa

A lysine to methionine substitution at residue 644 (K644M) was introduced into exon 10 of the gene along with a floxed neo cassette in intron 10. The mutation corresponds to K650M in humans (exon 15), which is associated with severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN). (J:70061)