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中文
在插入了带有loxP位点的floxed TK-neo cassette以及分别位于上游和下游内含子的单个loxP位点后，Exon 3被标记。通过在正确靶向的ES细胞中短暂表达Cre重组酶，Exon 3被去除了。通过Western blot分析来自纯合突变胚胎产生的鼠胚胎成纤维细胞（MEFs），证实了基因表达的缺失。对MEFs的免疫复合物激酶实验显示，这些细胞中缺乏酶活性。(来源：J:69056)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
