删除了特定于卵子的exon 1o和靠近启动子的部分,替换成含 floxed HSV-tk-PGK-neo 标记的载体。通过在正确靶向的ES细胞中短暂表达Cre重组酶,移除了抗性元件。对同卵突变动物卵巢切片的免疫组化分析证实了突变卵子中基因表达的缺失。(来源:J:68455)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
2
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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