删除了特定于卵子的exon 1o和靠近启动子的部分,替换成含 floxed HSV-tk-PGK-neo 标记的载体。通过在正确靶向的ES细胞中短暂表达Cre重组酶,移除了抗性元件。对同卵突变动物卵巢切片的免疫组化分析证实了突变卵子中基因表达的缺失。(来源:J:68455)
Basic Information
129S1/Sv-Oca2+ Tyr+ Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count