这个基因在exon 1位置插入了一个内切lacZ-neo插件,导致其功能受损。通过分析肺组织的 Western blot,我们确认了纯合突变动物中基因表达的缺失。X-gal染色结果显示,靶向基因的调控元件指导了lacZ报告基因的表达。(来源:J:65133)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
--
15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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