Tg(Ckmm-Dmd)3Chmb

The transgene is composed of Dmd cDNA sequences from exon 1 and exons 63-79 which encode the C-terminus of the full-length protein. The transgene is fused to mouse the Ckmm promoter/enhancer, exon 1, intron 1, and part of exon 2, which drives espression in skeletal muscle. Specific expression of the transgene in skeletal and cardiac tissue of transgenic animals was confirmed by Western blot analysis. (J:21841)