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中文
在反向插入了HPRT cassette的带条纹肌特异性的exons 12和13。尽管靶向构建旨在敲除带条纹肌的同源基因，但目标等位基因是无功能的。有趣的是，杂合体显示正常的蛋白质水平，尽管mRNA水平大约减少了50%，且没有带条纹肌β或慢骨骼α同型异构体的补偿作用，这表明可能在翻译水平上存在补偿机制。(来源：J:45833)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
