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Exons 3 through 7 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 245 amino acids encompassing the start codon, a conserved STAT motif, positively charged residues involved in intracellular anion binding, and the first 5 of the the 12 transmembrane domains. Neither transcript nor protein was detected in homozygous mice by RT-PCR and Western blot analyses. (J:79029)